Effect of the Cry1Ac toxin from Bacillus thuringiensis over the growth of some allergenic fungi isolated from patients whose suffer from allergic rhinitis
DOI:
https://doi.org/10.33885/sf.2009.3.1045Keywords:
Diagnostic, inhibitory effect, microbial identificationAbstract
Cry1Ac is a potent mucosal adjuvant. This work was undertaken to evaluate the
effect of the Cry1Ac toxin from Bacillus thuringiensis over growth up of allergenic fungi. The
fungi were isolated from nasal exudates in patients with diagnostic of allergic rhinitis and
positive skin prick test to allergic fungi. The fungi isolated were identified morphologic and by
Biolog system and agar diffusion test was done to evaluate the effect of the Cry1Ac toxin over
the fungi growth up. The following fungal genera were identified: Absidia, Aspergillus,
Alternaria, Penicillium, Eupenicillium, Fusarium and Cladosporium. The highest inhibition of
growth was obtained for Alternaria to a concentration 31.25 μg/mL of toxin. This inhibition
corresponded to 100% of the inhibition achieved with Amphotericin B. We suggest to
explore the inhibitory effect of Cry1Ac on the growth up of different genera and species of
pathogenic fungi via molecular standardized assays
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